DECRYPTION – While a study shows that saliva PCR tests more effectively detect the Omicron variant, the High Authority for Health announced at Figaro that she could review her recommendations.
Children screaming and crying, parents at the end of their rope who hold them at arm’s length … For the past few weeks, pharmacists and laboratory assistants have witnessed chaotic scenes in the screening rooms. “A real museum of horrors», Breathes Lionel Barrand to the Figaro. The cause of this mess? Repeated nasopharyngeal tests in the youngest, health protocol for holding schools in the face of the Covid-19 epidemic.
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However, to know the possible infection of a child with the virus, it was not always necessary to insert a cotton swab in his nostrils. More accessible and less traumatic, the saliva test has long been one of the government’s trump cards in the campaign to screen young people. If these tests were extended on a large scale in schools, many dysfunctions had however been reported, especially in terms of organization.
Today, they have completely disappeared from the new health protocol announced Monday, January 10 by Jean-Michel Blanquer. From now on, students in contact with a positive case will have to perform three self-tests: one on the day of the announcement of a student’s positivity, another on D + 2 and one on D + 4.
Underrated, yet reliable tests
Before this date, data from the Research, Studies, Evaluation and Statistics Department show that PCR saliva tests were still widely used in France, following the rhythm of school holidays, as is possible. see it in the diagram below.
However, we note, compared to saliva tests, that PCR and antigen tests are much more used, reaching a peak of just over 1,800,000 tests validated between December 19 and December 29 for those under 15 years old.
So why are saliva tests less highly rated? Is it for a reliability problem? “Not at all», Says Doctor Lionel Barrand, president of the union of medical biologists. These tests, carried out using the saliva sample, “are PCRs, therefore much more reliable than an antigen test and obviously a self-test», He recalls.
here is reliability rates different tests:
- Nasopharyngeal PCR: between 90 and 95% reliability
- A salivary PCR: between 85 and 90% reliability.
- A nasopharyngeal antigen test: 65% for all people, 44% for asymptomatic cases.
- A salivary antigen test: the High Authority for Health had estimated a reliability between 12 and 89% for symptomatic patients and between 9 and 50% for asymptomatic.
- A self-test: less than 65% for all people and less 44% for asymptomatic cases.
SEE ALSO – Covid-19: in Montpellier, these researchers created a new saliva test in three months
The Omicron question
The Omicron variant, however, leaves uncertainties as to the reliability of all these tests, notes Dr Barrand: “Viral loads are lower, so these tests that detect high viral loads detect a little less“.
Depending on the confirmation of this hypothesis, we may have to revise the recommendation for saliva sampling.
The High Authority for Health
On this question, the Haute Autorité de Santé, questioned by the Figaro, explains having a study which would suggest that salivary RT-PCR would become as efficient as PCR nasopharyngeal, see more : “There may be a greater replication in the oral compartment», Says Cédric Carbonneil, head of the Service for the evaluation of professional acts at HAS. “Depending on the confirmation of this hypothesis, we may have to revise the recommendation for saliva sampling.“.
The HAS also specifies to review its analyzes on antigenic salivary tests, whereas it had issued a negative opinion last spring. “An update of this opinion is underway in view of new studies on the subject.», Cédric Carbonneil tells us. “Very soon, we will either have to confirm that there is no relevance to using salivary antigenic tests, or on the contrary to perhaps use them in symptomatic or asymptomatic patients.He adds. According to him, this update should arrive at the end of January.
A problem of time, cost and capacity
While the reliability of PCR saliva tests has been demonstrated, why then are they less used? “It’s a cost and capacity issue», Then affirms Doctor Lionel Barrand.
First, because doing a saliva test implies that the child will be absent from school for a day and that potentially the parent will have to be absent from work for a day. Indeed, the results can take 24 hours for a PCR, while an antigen test or a self-test 15 minutes. Especially since it is more difficult to find a place to be tested in laboratories, the latter are overwhelmed with the number of contaminations, reaching 200,000 to 300,000 cases in recent weeks.
Then, because the Ministry of National Education announced “the end of quantitative objectives for saliva campaigns“, Specifying that”these could however be continued in agreement with the ARS and depending on the availability of laboratories», Could read the Figaro in a note.
For medical biologists, “the self-test has an interest and doing only saliva PCR would not be possible. “ On the other hand, Dr Barrand would have considered a different protocol at school: “Rather than having this scheme with three self-tests, the saliva PCR test should be done rather between D + 5 and D + 7 with self-tests before“. And to conclude: “It takes a good test for the right people“.