Third dose of Covid-19 vaccine: should serological tests be required to check the level of antibodies?

THE CHEKING PROCESS – The infectious disease specialist Robert Sebbag proposes to perform these tests to check his level of antibodies before being injected a third dose of anti-Covid-19 vaccine. But Prof. Delfraissy, chairman of the scientific committee, deemed the idea unnecessary at this stage.

THE QUESTION. The High Authority for Health (HAS) recommended Tuesday August 23 a third dose of vaccine against Covid-19 to all people 65 years of age and over, as well as to those at risk of severe forms of the disease. A recommendation that the government has chosen to follow. Guest of the “Grandes Gueules” of RMC, Professor Robert Sebbag, infectious disease specialist, estimated Wednesday that it would be good to carry out preliminary serological tests to check the level of antibodies – which would not necessarily drop in all vaccinated. “We have no real notion of the duration of the immunity. The preliminary serology will allow us to know what the level of antibodies is, he argued then. There is one piece of data that we do not yet know, and that is the importance of cellular immunity. You have humoral immunity, these are the neutralizing antibodies, which we know, that we know how to dose. But cellular immunity is much more complicated. So before automatically launching a third dose, we have to see if there is a drop in antibodies and if so, we can give the third dose. ”

Asked about this subject Thursday morning on Europe 1, Prof. Jean-François Delfraissy, chairman of the scientific committee, however felt that it was not necessary for the time being: “To date, we do not have good correlates of protection. That is to say that we do not have, with a blood test that allows you to look at your immune system, tests that allow you to say: ‘yes, on that date, I am still protected or I am not protected ‘. For the moment, it is not strong enough ”.

Would doing a prior serological test make it possible to avoid an unnecessary third dose of anti-Covid-19 vaccine? Or would it be ineffective to know the level of protection of the organism, as suggested by Pr. Delfraissy?

CHECKS. A vaccine induces

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