Why test-tube successes against the coronavirus are struggling to be confirmed in humans

DECRYPTION – An international team has deciphered a mechanism induced by many drugs tested in vitro, deleterious for the virus but unusable in practice.

Testing drugs already authorized in humans, which we have good reason to believe will be effective in Covid-19: the approach is attractive as it seems to promise savings in time and money. With a new molecule, about fifteen years can elapse between the validation of the pharmacological hypothesis and the arrival of the product on the market. Develop the drug, test its efficacy and toxicity in animals and then, in careful stages, in humans …

The repositioning of already known molecules exempts researchers from many of these long and tedious steps, and never have the attempts been as numerous as during the emergency of the start of the Covid-19 pandemic. Several thousand molecules have been tested and many have shown positive results. in vitro… before struggling to transform the test in vivo.

Among the many works launched around the world, an international collaboration bringing together the University

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